Section 1 General principles
1 What is pharmacology?
2 How drugs act:general principles
3 How drugs act:molecular aspects
4 How drugs act:cellular aspects – excitation, contraction and secretion
5 Cell proliferation, apoptosis, repair and regeneration
6 Cellular mechanisms: host defence
7 Method and measurement in pharmacology
8 Absorption and distribution of drugs
9 Drug metabolism and elimination
10 Pharmacokinetics
11 Individual variation, pharmacogenomics and personalised medicine
Section 2 Chemical mediators
12 Chemical mediators and the autonomic nervous system
13 Cholinergic transmission
14 Noradrenergic transmission
15 5-Hydroxytryptamine and the pharmacology of migraine
16 Purines
17 Local hormones 1: histamine and the biologically active lipids
18 Local hormones 2: peptides and proteins
19 Cannabinoids
20 Nitric oxide and related mediators
Section 3 Drugs affecting major organ systems
21 The heart
22 The vascular system
23 Atherosclerosis and lipoprotein metabolism
24 Haemostasis and thrombosis
25 Haemopoietic system and treatment of anaemia
26 Anti-inflammatory and immunosuppressant drugs
1 What is pharmacology?
2 How drugs act:general principles
3 How drugs act:molecular aspects
4 How drugs act:cellular aspects – excitation, contraction and secretion
5 Cell proliferation, apoptosis, repair and regeneration
6 Cellular mechanisms: host defence
p 78 , inflam episode – redness , swelling, heat , pain , loss fn
inflam mediator
cellular – host defence reponse
action of anti-inflam , immunosx drug – major class therapeutic agent
Introduction
immune – innate , acq(adaptive) immune system <- inflam response
main fn of host inflam – defence and repair
immunedef – eg genetic – leukocyte adhesion def
– infect c organism eg HIV ,
– radiation , immunosx drug
Innate – non-adaptive reponse
– early evolution , multicellar organism
– first line of defence
Adaptive immune – later , พบในvertebrate animal
– memory
– 2nd supremely effective
Innate Immune response – mucosal epithelial tiss – constantly secrete antibac prot eg – defensins รวมกับ all purpose Ig A เป็น sort of pre-emptive defensive
activated immediate หลัง – infection , injury
พบ all organism , first identify ใน plant ,insects
Pattern recognition = organism decide ว่า cell – bona fide citizen or invading
ต้องผ่านทาง network pattern recog receptor – PRRs <- พบทุก organism
recognise pathogen-asso molecular pattern (PAMPs) มักจะเป็น bac , fungi , virus
p 79 PRRs include G prot couple receptor eg FRR(formyl peptide receptor) , – recog N-formylated peptides