1: Molecular Structure and Function of the Skin Barrier
2: Mathematical Models in Percutaneous Absorption
3: In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/Vehicle Partitioning
4: The Skin Reservoir for Topically Applied Solutes
5: Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying the Interaction of Chemicals and Human Skin
6: Variations of Hair Follicle Size and Distribution in Different Body Sites
1: Molecular Structure and Function of the Skin Barrier
2: Mathematical Models in Percutaneous Absorption
3: In Vivo Percutaneous Absorption: A Key Role for Stratum Corneum/Vehicle Partitioning
4: The Skin Reservoir for Topically Applied Solutes
p 65 , 4.1 Introduction เป็นอันสำคัญในการ determine duration action of topical solute
reservior – สามารถมีได้ใน stratum corneum , viable avascular tiss(viable epidermis , supracapillary dermis) และใน dermis
steroid reservior in SC – reactivation of vasoconstrictor effect โดย occlusion /application of placebo cream to skin
other solute ก็ยังมี reservoir effect skin after topical application
why reactiveation of vasoconstrictio at some time after ทายา -> dependency on time , topical solute conc ,product use cause reactivation
solute ที่มีผล – potentially affected by desquamation ดฉถ้ามี turnover of skin abn rapid
promotion of reservior fn in viable tiss in dermis – effective removal by bl perfusing tissue
simple pharmacokinetic model
p 66 , diffusion model in series , convectiveการพาความร้อน loss of squamae from SC ->จาก desquamation
4.2 What is skin reservior , understanding in nature important ?
tp (topical application) 5% of all product – ใช้เพื่อ therapeutic purpose
อื่นๆ – cosmetic / cosmeceutic
tp – เราจะ concern เกี่ยวกับ efective penetration agent , -> เกิด local /system effect
env toxicology , undesirable penetration
amount of solute release – sufficient – สำหรับ yield pharmacological action , replicate observe เมื่อ 1st solute applied
phenomenon นี้เรียกว่า reservoir effect -> คล้ายๆกับ reactive steroid vasoconstrictor effect เมื่อ occlusive dressing applied original steroid application site หลายๆ wk หลังจากใช้คร้งแรก
limited steoid or to SC
4.3 Historical perspective on SC reservoir for drugs
5: Chemical Partitioning into Powdered Human Stratum Corneum: A Useful In Vitro Model for Studying the Interaction of Chemicals and Human Skin
6: Variations of Hair Follicle Size and Distribution in Different Body Sites