Part 1 Ionotropic glutamate receptors
1. Ionotropic glutamate receptors: functional and pharmacological properties in relation to constituent subunits
2. Structure of ionotropic glutamate receptors
3. Glutamate receptor trafficking
4. Pharmacology of NMDA receptors
5. Pharmacology of AMPA/kainate receptors
Part 2 Metabotropic glutamate receptors
6. Metabotropic glutamate receptors (mGluRs): structure and function
7 Pharmacology of metabotropic glutamate receptors
PART 3 GABAA receptors
8 Insights into GABAA receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors
9 GABAA receptor complex: structure and function
10 Ligands for the GABAA receptor complex
PART 4 Metabotropic GABA receptors
11 Molecular structure of the GABAB receptors
12 Pharmacology of GABAB receptors
PART 5 Glutamate and GABA transporters
13 Structure, function and regulation of glutamate transporters
14 GABA transporters: functional and pharmacological properties
PART 6 Pathophysiology and therapeutic prospects
15 Transgenic models for glutamate receptor function
16 Transgenic models for GABAA-receptor function
17 Glutamatergic transmission: therapeutic prospects for schizophrenia and Alzheimer’s disease
18 Modulators of the GABAA receptor: novel therapeutic prospects
1. Ionotropic glutamate receptors: functional and pharmacological properties in relation to constituent subunits
p 3 , ionotropic glutamate receptor – fast excitatory transmission หลายๆ central synapse
fusion of presynapstic vesicle c nerve-terminal memb – allow ให้ release packet glutamate เข้าไปใน synaptic cleft
short-lived chemical signal – convert -> electrical event เมื่อ neurotransmitter molecue bind กับ receptors
openign ion channels ใน postsynaptic memb
2. Structure of ionotropic glutamate receptors
3. Glutamate receptor trafficking
4. Pharmacology of NMDA receptors
5. Pharmacology of AMPA/kainate receptors
6. Metabotropic glutamate receptors (mGluRs): structure and function
7 Pharmacology of metabotropic glutamate receptors
8 Insights into GABAA receptor complexity from the study of cerebellar granule cells: synaptic and extrasynaptic receptors
9 GABAA receptor complex: structure and function
10 Ligands for the GABAA receptor complex
11 Molecular structure of the GABAB receptors
12 Pharmacology of GABAB receptors