Section 1: General Pharmacological Principles
1. Introduction, Routes of Drug Administration
2. Pharmacokinetics: Membrane Transport, Absorption and Distribution of Drugs
Section 3: Autacoids and Related Drugs
11. Histamine and Antihistaminics
12. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine
13. Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor
14. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics
15. Antirheumatoid and Antigout Drugs
11. Histamine and Antihistaminics
p 159 , histamine แปล “tissue amine” , certain plants eg stinging nettle -พืชมีพิษ
พบโดย Dale ต้น ศต 20
action , manifestations of certain allergic reaction
mediator hypersensitivity phenomena , tiss injury reaction
histamin เก็บ storage ใน granules of mast cell – พบมากที่ skin, gastric , intestinal mucosa , lungs, liver, placenta
ส่วน nonmast cell histamin – พบใน brain , epidermis , gastric mucosa, หรือ growing region
turnover of mast cell histamine – ต่ำ , แต่ถ้าเป็น nonmast cell histamine จะเร็ว
histamine พบใน bl , body secretion , venoms and pathological fluids
Synthesis , storage and destruction
12. 5-Hydroxytryptamine, its Antagonists and Drug Therapy of Migraine
13. Prostaglandins, Leukotrienes (Eicosanoids) and Platelet Activating Factor
14. Nonsteroidal Antiinflammatory Drugs and Antipyretic-Analgesics
15. Antirheumatoid and Antigout Drugs