1. The Structure and Function of Skin
2. Common Skin Disorders and Their Topical Treatment
3. Basic Mathematical Principles in Skin Permeation
4. Skin Transport
1. The Structure and Function of Skin
p 12 , skin 10% body mass
4 layers – stratum corneum – nonviable epidermis
– epidermis
– dermis
– subcu
several appendages – hair follicle , sweat duct , apocrine glands , nail
p 13
1940- topical anti-infective and hormonal agents
modern transdermal patch 1970
local effects – eg corticosteroid for – dermatitis
transport ผ่าน skin – systemic effect – eg nicotine patch for smoking cessation
surface effect – sunscreens , cosmetic , anti-infective
target deeper tiss – NSAID for m inflam
unwanted absorb eg solvents in workplace , agriculture chemical , allergens
p 14 , 1 ผ่านทาง sweat ducts
3 ทาง hair follicle
p 15 , นิยมผ่านทาง skin เพื่อ – avoid problems of stomach emptying , pH effects , enzyme deactivation asso GI passage