Part I Advance Recognition and Protection of Those at Risk of Acute Aortic Dissection
1. The Clinical Genetics of Thoracic Aortic Disease
2. When Should Surgery Be Performed in Marfan Syndrome and Other Connective Tissue Disorders to Protect Against Type A Dissection?
3. The Aortopathy of Bicuspid Aortic Valves
4. Size Matters: Intervention Thresholds for Dissection Prophylaxis in the Ascending Aorta
5. The Exostent Versus Alternative Strategies: The Role of an External
Support Sleeve in Aortic Prophylaxis
1. The Clinical Genetics of Thoracic Aortic Disease
p 3, genetic basic of thoracic aoritc disesae
several syndromic and nonsyndromic
Dysregulation of TGFβ signaling pathway และ dysfn contactile apparatus of smooth m cell <- เป็น Key
และอันนี้นำให้เกิด new Rx strategies , gene-tailored Mx guideline
Clinical Genetic -> Marfan syndrome , Loeys-Dietz syndrome
Introduction – ถ้าไม่ Rx – Aoritc aneurysm นำไปสู่ life-threatening ทั้ง – dissection and rupt 1-2% mortal of Western world ^ถือว่าเยอะมาก
Thoracic aortic aneurysm ถือว่าพบน้อยกว่า AAA
p 4, Marfan Syndrome
Freq , Inheritance , Dx criteria
2. When Should Surgery Be Performed in Marfan Syndrome and Other Connective Tissue Disorders to Protect Against Type A Dissection?
3. The Aortopathy of Bicuspid Aortic Valves
4. Size Matters: Intervention Thresholds for Dissection Prophylaxis in the Ascending Aorta
5. The Exostent Versus Alternative Strategies: The Role of an External
Support Sleeve in Aortic Prophylaxis