1 Historical Aspects
Part I Basic Features
2 Mechanisms in Allergic Contact Dermatitis
3 Molecular Aspects of Allergic Contact Dermatitis
4 Mechanisms of Irritant Contact Dermatitis
5 Immediate Contact Reactions
6 Mechanisms of Phototoxic and Photoallergic Reactions
1 Historical Aspects
2 Mechanisms in Allergic Contact Dermatitis
p 26 , 2.1 Introduction – Tcell mediator , จาก thymic และ recirculation pattern
identification gene determine T-cell fn
develop of monoclonal Ab, recog product ของมัน
bio-industrial product of large product eg cytokines , chemokine , breeding of mice c disruption in distinct gene (knock-out mice)
additional gene interest – transgenci mice
humoral Ab-mediated reaction ก็อาจจะเป็น factor
ACD – primary ขึ้นกับ activation allergen-specific T-cell, prototype of delay hypersensitivity
cell-mediated immunity นี้ develop ใน vertebrate เพื่อกำจัด microorganism, toxin
3 Molecular Aspects of Allergic Contact Dermatitis
4 Mechanisms of Irritant Contact Dermatitis
5 Immediate Contact Reactions
6 Mechanisms of Phototoxic and Photoallergic Reactions