Polyglot
Part I – Pathophysiology
1 Geneteics in Asthma
2. Group 2 Innate Lymphopid Cells and Asthma
3. Cellular Mechanism of Allergic Airway Inflammation
Chapter 1 Geneteics in Asthma
p 3 , asthma เป็นcomplex disease , interaction ระหว่าง genetic – environmental factor
heritability – 50%
GWAs – Genome-wide asso studies
Gene identified by hypothesis-drivent 4 type
1. innate immunity and immunoregulation
2. differentiation and regulation of T-helper 2 cells
3. airway epithelial mucosal immunity
4. airway remodeling and lung fn
genomic variant – อธิบายคนไข้ small porpotioin of asthma heritability
ศึกษา 2 approach- hypothesis-driven candidate gene asso และ hypotehsis-free GWASs
p 4 , 1.2.1
2. Group 2 Innate Lymphopid Cells and Asthma
3. Cellular Mechanism of Allergic Airway Inflammation